CD33 antibody (AA 15-237)

Catalog No. ABIN1845398

The Mouse Monoclonal anti-CD33 antibody has been validated for FACS, WB, IHC and ELISA. It is suitable to detect CD33 in samples from Human.

Quick Overview for CD33 antibody (AA 15-237) (ABIN1845398)

Target: CD33

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD33 antibody is un-conjugated

Application: Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-CD33 Antibody

Binding Specificity: AA 15-237

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human CD33 (AA: 15-237) expressed in E. coli.

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: PBS with 0.05 % sodium azide and 0.5 % protein stabilizer.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.

Target Details for CD33

Target: CD33

Alternative Name: CD33

Background: The protein encoded by this gene belongs to putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells.Preferentially binds to alpha-2,6-linked sialic acid.The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase (s) via their SH2 domain (s) that block signal transduction through dephosphorylation of signaling molecules.Induces apoptosis in acute myeloid leukemia (in vitro) and CD33 plays potential key roles in the pathogenesis of Alzheimer's disease (AD).

Molecular Weight: 39.8 kDa

Gene ID: 945

UniProt: P20138